Your question about whether I prefer Juvederm Voluma versus Radiesse for large area volumizing, such as cheek hollows, is good one. The answer is, “It depends”. What it depends upon is what we need to do with the cheeks and how heavy the skin is. Juvederm Voluma is a soft, cushiony, very natural cheek builder. It will give a pillowy cheek with soft contour. On the other hand, some patients have larger faces and heavy skin and in order to lift the cheeks and create cheekbones we actually need something with greater thickness that is less prone to flattening. That filler would be Radiesse. There is a property called G prime that refers to how easily it can be compressed or flattened. It turns out that Radiesse has the highest G' of all the fillers and Juvederm Voluma is in the middle. Sometimes I want to really lift the cheeks or create a sharp contour with the cheekbones. Then my choice would be Radiesse. Other times I want to soften and smooth irregularities, lift to some degree, or the skin may be thinner and we want something more forgiving. In that case I would choose Juvederm Voluma. Both products stimulate the production of new collagen and are capable of giving a long-term result of a year or longer. Radiesse stimulates collagen a bit more and Juvederm Voluma may last a bit longer due to its Vycross technology. Both are excellent products for the cheek. Again, it depends on each patient’s individual face. One advantage of Juvederm Voluma is that it is composed of hyaluronic acid. This is a substance that we can dissolve, should you not like the look of your cheeks or should there be any rare adverse effects. Other non-hyaluronic acid fillers cannot be dissolved, but they will just wear away naturally. With a board certified dermatologist who is experienced in many fillers, this difference should not be an issue. For cheek hollows that are lower down in the face, I sometimes prefer Juvederm Voluma or less thick versions like Juvederm Ultra, Ultra Plus or even something in the Restylane family, such as Restylane or the new Restylane Defyne. These products are a bit more light weight and will move naturally with smiling and other movement near the mouth. It is important to understand that we often mix and match these fillers in the face to choose just the right filler for that particular area. This is again a reason why you want to pick your provider to be someone who is very skilled in analyzing the face and choosing the right product for the right place.