Juvederm is FDA approved for placement in the nasolabial folds, which are the "parentheses lines" which extend from the outer edge of the nostrils to the corners of the mouth. This is the most common area for treatment but there are several other areas where the product works beautifully. These other areas are considered "off-label" but are perfectly safe to be treated in the hands of skilled and well-trained injectors. The other areas I commonly treat in my practice are the marionette lines (below the corners of the mouth), the lips, the cheeks, the nose, and along the jawline. Under the eyes, my personal preference is to use Restylane, another hyaluronic acid filler.
Juvederm comes in two forms: Ultra and Ultra Plus. Juvederm Ultra is great for filling closer to the skin, for treatment of superficial lines and lip augmentation. The Ultra Plus gel is better suited for deeper wrinkles and augmenting areas such as the cheek, where the skin is thicker and the product is placed more deeply. Also, both Juvederm and Restylane come in forms which are premixed with lidocaine, to help minimize discomfort from the injections.