I now have 2 much larger ones on the inner and upper part of both thighs which are not painful but bother me aesthetically. I've also had recurring left ankle, foot and calf swelling which gets worse as the day goes on. I've been taking Lasix 40 mgs. for approximately 6 months with no improvement. My question is could it be possible that the left lipoma is decreasing the blood flow to my left leg?