Before any advice is given, it's important to note that a physical examination and a detailed discussion with a trained healthcare professional or dermatologist are necessary to make an informed decision. However, I can provide general information on the procedures you mentioned. 1. Skin Pinch: This procedure is usually performed on the lower eyelids to remove excess skin and improve the appearance of wrinkles. Its effectiveness on smile lines or skin folds elsewhere on the face is not typically noted. 2. CO2 Laser: This treatment is effective for reducing fine lines, wrinkles, sun damage, and uneven skin tone. It works by removing layers of skin in a fractional method to promote new skin growth. It may be beneficial for your skin folds, but recovery could take up to two weeks. 3. Dermal Fillers: These are often used to smooth out lines and wrinkles by adding volume and fullness to the skin. They are commonly used on smile lines and could be a good option. The results are usually immediate and can last from six months to two years, depending on the type of filler used. Remember, the best treatment for you depends on your individual skin type, health history, desired results, and the expertise of the professional performing the procedure. Always consult with a qualified healthcare provider for personalized advice.