When managing hyperpigmentation following neurodermatitis flare-ups, it's important to choose products that are gentle on the skin and effective in reducing pigmentation. Here are some options that are generally considered safe: Hydroquinone: This is a common topical agent used for lightening hyperpigmentation. It works by inhibiting melanin production. However, it should be used under the guidance of a dermatologist to minimize potential side effects. Azelaic Acid: This is a naturally occurring acid that can help lighten skin by reducing melanin production. It also has anti-inflammatory properties, making it a good choice for sensitive skin. Niacinamide (Vitamin B3): Known for its skin-lightening properties, niacinamide can help with hyperpigmentation and also improve skin texture and barrier function. Vitamin C: Topical vitamin C can help lighten hyperpigmented areas by inhibiting melanin production and providing antioxidant protection. Kojic Acid: Derived from fungi, kojic acid is often used in skin-lightening products and can be effective for reducing hyperpigmentation. Licorice Extract: Known for its soothing properties, licorice extract can also help lighten dark spots. Retinoids: These can help with cell turnover and reduce hyperpigmentation over time. They should be used cautiously, especially on sensitive skin, and ideally under the supervision of a dermatologist. Before starting any new treatment, it's crucial to consult with a dermatologist to determine the best and safest option for your specific skin type and condition. Additionally, using a broad-spectrum sunscreen daily is essential to prevent further pigmentation and protect your skin.