Botox doesn't seem to work for me? (Photos)

I received Botox for the first time 3.5 wks ago. Was given 22 units between my eyebrows. After 2 weeks I had 90% mobility back in that area. Went back and got 14 more units. Noticed a difference for the first 3 days but now it's wearing off again. Why would this be? Am I immune? I'm a trainer and I work out rather intensively 5-6 days a week. Would that be a factor? Is there another product or procedure I should try or was it the technique used to inject was wrong?

Doctor Answers 8

Botox Not Working

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I am sorry to hear about your situation. It is very unusual for someone to not respond to Botox. Some patients due require more Botox then others. It could be possible that the injector’s technique was not good. Please make sure your injector is an expert. In addition, you may want to consider an alternative such as Dysport. It is highly unusual for Botox not to work.

Summit Emergency Medicine Physician
5.0 out of 5 stars 47 reviews

Botox between brows not working

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There are a variety of features that determine botox effectiveness including total dosing, reconstitution (how botox is mixed), injection placement, type of botox used (botox vs dysport vs yeoman) etc. Although physically active people tend to wear off botox sooner they still typically should get 2.5-3 months duration so 2 weeks is rather unusual. I recommend that you seek another expert injector to determine why your botox has not worked in the past. Alternatively, switching Botox preparation to another brand, for example Dysport could lengthen the overall duration of your result. 

Alternatively, your lines could also be corrected with injectable filler, for example restylane or emervel. Only expert injector should inject glabella as there are many blood vessels in that area and improper injection can lead to permanent adverse effects. 

Andrei Metelitsa, MD, FRCPC
Calgary Dermatologic Surgeon

Botox doesn't seem to work for me?

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It is very rare for someone not to respond to Botox.  On occasion patients do require more than average to have a good effect.  It is also possible that the injector's technique was not ideal, so make sure you are seeing an expert.  If it is an expert, he/she will be able to figure this out for you and get the results you are looking for.  Good luck!

Botox and Glabella Area

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I would return to your treating physician for examination since it sounds like you had a sufficient amount of Botox to have this area "frozen".  For the best cosmetic results please consult a board certified dermatologist.  Best, Dr. Green

Botox not working

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for someone who is young and strong as you are, the amount of Botox you had is rather below average. Add to that you lifestyle of hypermetabolism, it is possible that you ran through Botox very quickly. While you could try another injector or botulinum toxin product, there are now other options. 

For non-injectable, the Revision skin care line now has a topical that can "freeze" the area topically with a cream. Of course it is not as effective, but needle-less and not having to visit your doctor's office is attractive. 

Also, Thermi-tight has had some really wonderful results with targeted nerve ablation in which results are permanent. 

Botox Not Working

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There are a couple of reasons why Botox may not have worked for you. If your injector is not experienced then he/she may not have injected you correctly into the muscle. Very few people are actually "immune" or resistant to Botox. I would try a different injector. If it still doesn't work for you then you can try a Botox alternative such as Dysport or Xeomin. Just remember, though, you have deep lines at rest and those lines may not completely go away with Botox. Hope this helps!

Botox doesn't seem to work

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I would probably try a different injector.  There is an art to Botox injection and some injectors will achieve better results than others.  In my hands it would be very unusual for Botox not to work in the glabella or frown line area.  I usually start with 15-20 units and this is sufficient for most of my female patients.  Also, you could try two other Botox-like products, Xeomin or Dysport.  I use quite a bit of Xeomin in my practice with nice results.  Make sure that you are going to a reputable clinic.  In my office, I administer all Botox and filler injections myself.


Dr. Ort

Botox not working in frown line

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The problem is poor injection or resistance. I would try another provider. If not any better, I would try Xeomin. All providers are not the same. People that are gym rats do metabolize Botox faster, but that is probably 2 months duration, not days.

Steven F. Weiner, MD
Panama City Facial Plastic Surgeon
4.8 out of 5 stars 53 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.