Does Freezing Botox Change It?

It sounds like you may have some confusing information.  Botox is shipped from the manufacturer on dry ice.  It is then kept in the refrigerator at the recommended temperature until it is reconstituted and used.  Reconstituting it, means that you are mixing the dry powder in the vial with saline so that it can be injected with a syringe.  In general, the Botox should then be used within four hours, but some studies have shown that it last much longer.  In our office, we open a new vial for each patient and reconstitute it right infront of them and then inject it.  That way, the patient knows that they are getting the freshest Botox available and also that they are getting the whole vial.  It would be  inpracticel and unnecessary to use the Botox the day it arrives from the manufacturer. 

 

Good Luck.

When Botox first came out, we used to have Botox Days--we thought that it had to be mixed fresh and used that day or it would lose its potency. (As you have read, it comes to us as a freeze-dried product that is kept frozen until it is reconstituted with saline.) What studies have shown is that its potency will remain the same for two weeks or more. So, most of us keep it refrigerated (not frozen!) after reconstitution and use it for the next two weeks.

I suspect if a doctor is still doing Botox Days, they either have a very small volume of Botox patients, or they are uninformed.