Does Freezing Botox Change It?

Botox comes as a powder and is shipped on dry ice so it is frozen. It's not as if a physician gets it fresh and then can freeze it. Once the physician needs the Botox powder is mixed with a sterile liquid to make a solution. That solution is then kept refrigerated until the next dose is needed and in busy practices this might be less than one day. An expiration date or the date mixed is written on the bottle. Using fresh mixed or refrigerated Botox has not made any clinical difference when the stored time is less than two weeks.

Thank you for your question.

No, Botox does not need to be used the same day that it is shipped to the doctor. Please make sure that you are having a certified doctor perform the injections.  There are dentists, nurses, aestheticians, etc. who do Botox injections... be careful!

Hi Tilly's Mom.  Botox is freeze dried when it is received and not frozen.  Like any other pharmaceutical product, Botox has a useful shelf life and this shelf life changes once saline solution is added (reconstitution).  

As long as the Botox has not expired (which it rarely will at any office that uses it regularly), using it on the same day is no different than using it days or weeks later, especially if it has not been reconstituted.

It sounds like the MD that is purporting to use it on the same day is trying to use this as a marketing tactic to scare consumers into thinking this is the only way it will be useful.