I am bone on bone and trying to put off knee replacements. Had PRP (first time), at same time as the corizone and synvest shots which had before with no problems. Both knees swelled up like balloons two weeks later---now about to start my 4th week and the swelling gets worse even with Mobic and icing. Hope to see the doctor again but not sure what they can do or why reaction so bad. He mention maybe too much at one time.