For facial rejuvenation I would suggest a combination approach including: 1) Skincare with products and microneedling/PRP 2) PDT Light Therapy a few times per month with growth factors 3) Laser treatments like Clear + Brilliant regularly and others (Fraxel, Moxi, Viva, CO2, Erbium, Halo) a few times per year 4) Sculptra injections a few times per year for collagen production with fillers like Juvederm, Restylane, Belotero, Radiesse, and/or Bellafill 5) Thermage/Ultherapy for yearly skin tightening with or without PDO or cone-based Instalift threads for lifting 6) Botox every 2 to 3 months to stop movement lines and prevent lines at rest See an expert. Best, Dr. Emer