Deep/uneven folds - are fillers my only option? (Photo)

I’m almost 39, and I have a more pronounced fold and crease on my left side than right. It really bugs me. I had Botox for TMJ problems earlier this year. My left muscle was more overstressed and the Botox helped so much - I only did it for the pain relief and I’ve been please. Not sure if the jaw dysfunction impacted the way these folds formed or not. Are fillers my only option? I’m so self conscious about my smile now.