Possible to Have Fat Grafting on Legs?

Chances are that you want a significant volume to change the appearance of your calves.  The amount of fat needed may be too large for your calves as the fat may not get enough oxygen to survive. It might have to be performed over several sessions.  The risk of infection and lack of survival is greater in the leg because of less circulation in this region. See a board certified plastic surgeon.

Without a picture, it's hard to say whether fat transfer would be the solution you are looking for. You have to have enough fat to make up for the difference in volume, and you have to be prepared for the possibility of needing multiple sessions to get the desired result. Only a certain amount can safely be injected at one time and some of the fat can reabsorb after injection (up to 50% in some patients). Fat grafting would be most effective near major muscles (the calf, the quad) and less effective in bony areas (around the ankles and on the front of the leg) since it needs good blood flow to survive. It is certainly a safer option than implant surgery as far as long term risks like infection and scarring, but fat transfer to the legs is more risky than in other areas of the body, so I highly recommend going to someone with a lot of experience in fat transfer. You can be prepared to spend between $3000 and $6000 depending on the amount of fat, the number of areas treated, and how long it takes to perform the procedure.

It is possible to transfer fat to the legs but it is less than an ideal recipient site and more prone to complications such as fat necrosis (lumps & bumps) as well as infection because it tends to be less vascular and more prone to edema (swelling).