Thank you for your question. Profhilo skin booster treatments and polynucleotide treatments are generally well-tolerated, but caution is advised when planning any cosmetic procedures around the time you are starting Accutane (isotretinoin) therapy. Accutane can significantly affect your skin, making it more sensitive and prone to dryness, irritation, and slower healing. Given that you are planning to start Accutane in a month, it is crucial to consider the following: Timing and Healing: Profhilo and polynucleotide treatments should ideally be done well in advance to allow your skin sufficient time to heal before starting Accutane. While a month might be sufficient for some individuals, it is essential to monitor how your skin reacts to the treatments. Consultation with Your Dermatologist: Before proceeding with any cosmetic treatments, it is important to discuss your plans with your dermatologist. They can provide personalized advice based on your skin type, treatment goals, and the potential interactions with Accutane. Potential Risks: Starting Accutane can amplify the side effects and complications from recent cosmetic procedures. It is crucial to ensure that your skin is not compromised when beginning Accutane therapy. In summary, while it may be possible to undergo Profhilo and polynucleotide treatments a month before starting Accutane, it is essential to proceed with caution. A thorough consultation with your dermatologist will help determine the best course of action for your specific situation.