Hello, Thank you for your question and for sharing your concerns. Persistent acne and blackheads can be frustrating, but there are several effective treatment options you can consider. For the acne that has not fully resolved with Clindamycin 1%, you might benefit from a combination approach. Here are some suggestions: Topical Retinoids: These are very effective in treating acne by promoting cell turnover and preventing clogged pores. Examples include tretinoin or adapalene. Benzoyl Peroxide: This can be used in conjunction with topical antibiotics like Clindamycin to reduce bacterial resistance and enhance effectiveness. Oral Antibiotics: If topical treatments are not sufficient, oral antibiotics such as doxycycline or minocycline may be prescribed to reduce inflammation and bacterial growth. Hormonal Treatments: Sometimes, acne in adults can be influenced by hormonal imbalances. Medications like spironolactone can be useful, especially if the acne is resistant to other treatments. Chemical Peels: Procedures performed by a dermatologist, such as salicylic acid or glycolic acid peels, can help to exfoliate the skin and clear up acne. For the blackheads on your nose, consider the following: Salicylic Acid: This beta hydroxy acid (BHA) penetrates the pores and helps to dissolve the debris that causes blackheads. Exfoliation: Regular gentle exfoliation can help to prevent the formation of blackheads. Look for products with ingredients like alpha hydroxy acids (AHAs) or BHA. Extraction: Professional extraction by a dermatologist can safely remove blackheads without causing damage to your skin. It's important to tailor the treatment to your specific skin type and the severity of your acne. I recommend consulting with a dermatologist to develop a personalized treatment plan.