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Administering lip fillers while on Accutane (isotretinoin) is generally not recommended. Accutane can significantly affect the skin, making it more fragile and prone to complications such as scarring and poor wound healing. It is typically advised to wait at least 6 months after completing Accutane therapy before undergoing any cosmetic procedures, including lip fillers. This waiting period allows your skin to recover fully and reduces the risk of adverse effects. Please consult with your dermatologist to discuss your specific situation and the best course of action for your skincare and aesthetic goals.