Hi Cool809585,Since there’s limited information in your question, I’m going to make some assumptions. I’m assuming you’re heterozygous Factor V meaning you only have one allele of the gene. People with homozygous factor V have two alleles and typically present early in life with a clot and are on blood thinners for life, because their risk of future clots is extremely high. Factor V is the most common inherited hypercoagulable condition. Most people don’t know they have it unless they’ve had a clot or a family member with a clot. Therefore, a lot of people have it and don’t even know it. I’m sure we Botox numerous patients with heterozygous factor V that are completely unaware of their condition. If you have had a clot and are on blood thinners, then your risk of bruising from Botox would be increased. I would discuss it with your PCP prior to having any procedures but generally I would say it is safe and haven’t read anything or experienced anything otherwise. I hope this helps. Good luck!