Marionette lines are caused by soft tissue deflation and descent, loss of bony support in the jaw, and are exacerbated by the action of our "frowning" muscle. The best approach to this area is a combination of filler for the volume changes and a neuromodulator like Botox or Dysport for the "frowning" muscle action. Results are better with that combination and both last longer in combination, which is supported in the literature. I was quite surprised reading this that more physicians did not discuss the combination. To ensure you are receiving the highest level of care, seek out a modernly trained, new-school dermatologic surgeon, oculoplastic surgeon, facial plastic surgeon or plastic surgeon who is board certified and fellowship trained in one of these "core four" cosmetic specialties.Cameron Chesnut#realself500 Physician