The amount of tissue that can be reduced during breast reduction surgery depends on the multitude of variables. Without seeing pictures, we can’t make an assessment. A distance of the nipple to be inframammary. Fold is one variable that may limit how the procedure can be performed. Removing too much tissue can damage the blood supply to the nipple and areola leading to severe complications, including tissue necrosis. Sometimes the procedure can be altered. If it more drastic result is desired. This could include removing the nipple in areola and replacing them as free tissue grafts. In that case, there is no limit to how much tissue can be removed, but the outcome may not be aesthetically desirable. I suggest having a few in person, consultations for local board-certified plastic surgeons in your area. Best, Mats Hagstrom, MD