Many factors determine the duration of the effect of blepharoplasty. Tissue that is removed will not regenerate - that's good news - unless too much tissue is removed! There are general health issues that may intervene - hypertension/ ACE inhibitors, allergies, thyroid dysfunction, inflammatory diseases, ravages of smoking, etc. Mechanical trauma destroys the delicate peri-ocular tissues - eye-rubbing, applying and removing makeup (rubbing to get the makeup off), constant wiping with fingers or tissues. After blepharoplasty, one should avoid hand to eye contact as much as possible and use gentle makeup removal. Skin care is important as well. Best wishes with your decision.