What are risk factors for late-onset immune reactions to fillers? Can this reaction point to other issues with immune system?

Late-onset nodules are relatively rare after filler treatment, particularly with non-vycross fillers such as Restylane. Dental procedures before or soon after injection, poor injection technique, infection, and certain autoimmune diseases such as Rheumatoid Arthritis are thought to put a patient at increased risk of late onset nodules. The Vycross family of fillers which including Juvederm Voluma, Vollure, and Volbella have also been associated with a higher risk of late onset nodules although the reason for this is still unclear. I think it is important to have this discussion with your treating physician prior to your filler treatment since it concerns you enough to ask. 

Most physicians are not comfortable injecting fillers into the faces of patients with known auto immune diseases due to abnormal reactions to fillers including swelling and irritation This is the most common with Botox You may benefit from RF tightening and rejuvenation Good luck