34, female. Are Polynucleotides safe for under-eye wrinkles? (Photos)

Question

34F interested in the safest but most effective treatment for under-eye wrinkles. EZ PRF Gel had many negative reviews here and the cost was out of budget. I looked at some reviews for Polynucleotides and the results seemed to target fine lines at a more affordable cost per session. What is recommended here and what is the avg. cost per session? Thanks!

Behnoush Zarrini, MD · Answer

In my practice, polynucleotides can be a safe and appropriate option for under-eye wrinkles when they are performed by an experienced injector who understands the anatomy of the tear trough. They are not a filler and not a blood product&mdash;they are regenerative molecules that improve skin quality by stimulating hydration, collagen, and repair. The data we have shows they can improve fine lines, elasticity, and texture, with mostly mild side effects like temporary swelling or bruising . That said, the results are gradual and subtle, not immediate. If your concern is very fine crepey lines, they can be useful. If there is structural hollowing or shadowing, they will not replace volume the way filler or a properly designed regenerative protocol would.
In terms of cost, most patients can expect roughly $400–$900 per session, with a series of 2–3 treatments typically needed for visible improvement . That puts them in a similar or slightly lower range than PRF, which often runs higher per session. Between the two, PRF has the advantage of being derived from your own blood (very low risk), while polynucleotides are still considered safe but more “manufactured.” The right choice comes down to your anatomy and goal: skin quality vs. structural correction. In a 34-year-old, I rarely rely on one modality alone&mdash;the best outcomes come from choosing the correct tool for the exact cause of the wrinkle, not the trend.

Anna Chacon, MD, FAAD · Answer

Polynucleotides are generally considered very safe and well-tolerated for the under-eye area, especially for patients looking for a more natural regenerative approach.

They work by:

Improving skin quality and hydration
Stimulating collagen repair
Helping fine lines and crepey texture over time

That said, results tend to be subtle and gradual, not dramatic or immediate like filler.

In my experience:

They’re best for early fine lines, thin skin, and skin quality improvement
They are not a substitute for volume loss correction

As for cost, it varies by provider and region, but it is typically done in a series of treatments rather than a one-time session, since results are cumulative.

If budget is a concern, we often tailor a plan based on whether the goal is texture improvement vs true volume restoration, because those require different treatments.

34, female. Are Polynucleotides safe for under-eye wrinkles? (Photos)

Answers (2)

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