I'm on isotretinoin but my skin is still very oily and the acne hasn't improved, is the drug working?

Accutane is a go-to medication for patients with recalcitrant cystic acne. It can reduce pore size and also reduce sebum production in your skin, making it less oily; and in turn, dryer. Accutane can be used to control acne, but patients receiving the medication should be carefully monitored. In terms of skincare, always wear an appropriate sunscreen and reduce direct sun exposure. In my patients, I recommend a good ceramide moisturizer such as Elevase whenever they are on Accutane. This will keep the skin hydrated and reduce the oiliness of the skin that is associated with oil-based moisturizers.

Best,
Dr. Karamanoukian
Realself100 Surgeon

Most patients are taking accutane for 3 month or longer.   So if you have only been taking the medication for 2 weeks, I don't think you will start seeing the results that you are looking for.   So continue to take the medication as long as there aren't any side effects and be patient.

Thank you for your question. Results with Accutane therapy vary per individual. In my opinion, two weeks of therapy is too soon to notice any improvement with your acne. Also, your progress may be related to the dose you are taking daily. Accutane dosing is based on your weight, which is 1 mg per kilogram for 4 months; therefore, if you are taking a low dose, then improvement and side effects may be minimal. The dryness that you were told you will experience is related to the dose you are taking, which means the higher the dose, the more dryness you will experience. I highly recommend you consult with your prescribing physician regarding your concerns and questions. Take care and good luck.