Botox and Hylenex in the same day? Will Hylenex effect the Botox? (Photos)

Question

Hello! Can Botox injections + Hylenex be used in the same area—same day? I had tear trough filler (silk). I’d like to schedule an appointment for Botox (crows feet) soon + Hylenex for my under eyes. Will Hylenex effect the Botox? Can both be applied on the same day? Suggested order; Botox 1st + then Hylenex? Vice versa? Suggested time frame for each, assuming they can’t be done same day? TX laws, fake reviews and lots of new Drs. and medspas make it hard to know the truth these days. TIA!

Edward Buckingham, MD · Answer

There is not any science to support having or not having hylanex and Botox in the same day.  However, theoretically, the Hylanex could cause diffusion of the Botox if the injections area is not separated by a reasonable distance.  I would suggest not combining.  There isn't really a downside, except lost time, to separating the treatments, and there could be a problem.  I would suggest playing it safe and separating the treatments.

Tanya T. Khan, MD · Answer

You should space the treatments apart by a few days at least just to minimize the chance that hylenex will not cause further dissolution of product and potentially compound your Botox results. I think Hylenex first, then Botox. Not the same day.

Georgios Ziakas, MD, FACS · Answer

Hylenex will dissolve the filler but has no effect on the mechanism of action of the Botox. In theory it may cause Botox to dilute or migrate if it is injected in the same area.

Shaun Patel, MD · Answer

Yes, I believe it would be alright for you to have both treatments on the same day as long as you are seeing an experienced injector. However, if the filler was done recently, you may want to give the swelling some time to resolve.

Jeffrey W. Hall, MD · Answer

Both Hylenex and Botox work with different mechanisms. Therefore, they can be injected at the same time without changing their effects especially since they are being injected into two different areas. Your pictures look as though the filler was injected into the tear trough may be into the lower lid area causing the fullness. This is a very difficult area to treat and it makes sense to inject the Hylenex to dissolve it.

Botox and Hylenex in the same day? Will Hylenex effect the Botox? (Photos)

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Answer: Hylenex and Botox treatment on the same day

Answer: Hylenex and Botox treatment on the same day

Answer: Hylenex and Botox

Answer: Hylenex and Botox

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Botox and Hylenex in the same day? Will Hylenex effect the Botox? (Photos)

Answers (7)

Answer: Hylenex and Botox treatment on the same day

Answer: Hylenex and Botox treatment on the same day

Answer: Hylenex and Botox

Answer: Hylenex and Botox

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Recommended reading

Everything you need to know about Botox

Our mission is to create a world where every investment in modern beauty is Worth It.