Can I Apply Latisse over Tretinoin? Is It Safe?

Latisse is applied to the upper eyelid margin while Tretinoin should not be applied to the eyelids.  This will cause dryness, redness as the skin of the eyelid is very thin.  Additionally, the retinoins are not formulated for application of the eyes and may cause burning and irritation.

Tretinoin, a vitamin A derivative, is used for the treatment of photoaging, brown spots, fine wrinkles as it causes new collagen production.  Although this is widely used on the face with a pea-sized evening applicaiton, I specifically instruct patients to avoid use around the eye area and corners of the mouth.  The delicate skin of the eyelid is easily irritated, and tretinoin is likely to cause an inflammatory reaction.  Latisse is to be used on the upper eyelash line nightly--therefore, one should not be used in the same area as the other.