Is the line there only after Botox - and it resolves as the Botox wears off? If so, then it has do with the way the facial muscles are being pulled (or not pulled as the case may be) while relaxed with Botox. There may be ways to adjust the injection sites if it is directly attributable to the botox
Botox into the chin or mentalis muscle can help with dimpling of the chin and decrease the pebbled appearance of the chin. Depending of the direction of the muscle pull it can also subtly alter the chin shape.
It's understandable that you're frustrated with your asymmetrical smile, especially when it's something you've dealt with for a long time. While fillers can enhance lip volume, they may not fully address underlying muscle imbalances that contribute to smile asymmetry. Here's some advice on...