Can Hyaluronidase dissolve your own natural tissue? If it does, is it permanent?

Dear adrii34,
hyaluronidase is an enzyme which affects only hyaluronic acid and not normal tissues. If you have problems with your fillers, then I suggest you to consult your plastic surgeon or injector.
Daniel Barrett, MD

We do not think that h-dase breaks down naturally occurring hyaluronic acid to any significant degree and so it should be safe to use in breaking down injected HA fillers.  I hope that helps and wish you the very best!Warmest regards,-Gregory A Buford MD FACS PCEOBoard Certified Plastic Surgeon and Published AuthorCertified Allergan MASTER Facial Injectables Trainer

Hyaluronidase will not result in long term changes to your natural tissues. It will dissolve HA filler and naturally occurring HA, but the latter is replaced over the first few days after treatment.