It's commonly agreed upon protocol among core aesthetic physicians that ablative (even partially ablative) skin procedures should be postponed for 6 months after Accutane. However, I would not place microdermabrasion in that category and we have plenty of patients who have done...
Both Accutane and St John's Wort cause the skin to be more light sensitive. Together they can cause a severe phototoxic reaction. So this combination is not recommended.
The question is did these mood changes start while on Accutane? There is no evidence of Accutane causing...