Long-term use of Accutane (isotretinoin) is generally not recommended due to potential side effects and risks. Here are some important considerations: Typical Treatment Duration: Accutane is usually prescribed for a course of 15 to 20 weeks, depending on the severity of the acne. Some patients might require a second course if acne recurs, but continuous use over several years is uncommon. Potential Side Effects: Long-term use of Accutane can increase the risk of serious side effects, including liver damage, high cholesterol and triglycerides, bone density loss, and mental health issues such as depression. Regular monitoring by a healthcare provider is essential if you are on Accutane for an extended period. Alternative Treatments: Since you have been on Accutane for a prolonged period without sustained results, it may be worth exploring other treatment options. These could include hormonal treatments (like the oral contraceptive you mentioned, Jaz), spironolactone, topical retinoids, or other medications. A dermatologist can help tailor a treatment plan based on your specific needs. Lifestyle and Skincare: In addition to medication, maintaining a consistent skincare routine and making lifestyle changes, such as a balanced diet and stress management, can help manage acne. Consultation with a Dermatologist: Given your situation, it is crucial to discuss your concerns and experiences with a dermatologist. They can assess your condition, monitor for any side effects, and adjust your treatment plan accordingly. It's important to address these concerns with your healthcare provider to find a safe and effective long-term solution for your acne.