Profhilo is a unique injectable hyaluronic acid treatment, designed to boost skin hydration, support, tautness and elasticity. This clear, aqueous substance is a mix of high and low molecular weight, pure hyaluronic acid (HA), without the cross-linking chemicals found in hyaluronic acid-based dermal fillers.Â
When injected into the face, neck, décolletage, inner arms, thighs, or the backs of the hands, it spreads evenly throughout the skin. Unlike most hyaluronic acid injectables, Profhilo isn’t a dermal filler treatment per se, or even a simple “skin booster”; it’s a type of injectable described as a "bio remodeling" agent, according to Dr. Nelson Lee Novick, a board-certified dermatologic surgeon in New York City and Clinical Professor of Dermatology at Mount Sinai School of Medicine.
“Profhilo works by stimulating collagen and elastin production by fibroblasts in the dermis and keratinocytes in the epidermis, as well as by preserving the health and vitality of the fat cells in the subcutaneous tissue,” Dr. Novick explains. “The result is greater skin support, diminished laxity, and improved suppleness that translates into plumper, more dewy, more youthful skin.” Â
Although this treatment won’t change face shape or erase deep wrinkles, the benefits of Profhilo injections include a subtle improvement in overall skin quality and fewer fine lines, for smoother, brighter skin.
Profhilo is not yet FDA approved, so it’s not officially available in the U.S., but clinical trials are ongoing. However, it has been widely available in Europe and other parts of the world since 2016.
Until recently, Dr. Novick also had a practice in Israel, where he frequently treated patients with Profhilo. "I have personally been injecting Profhilo routinely in my satellite practice abroad for over six years, treating crinkling, crepiness, and mild laxity of the face, neck, decolletage, abdomen and upper arms and upper thighs.” He says the results have been “very gratifying, especially when combined with other HA fillers."
