Juvederm Side Effects

I'm thinking of having Juvederm for deep wrinkles between brows. Are there any side effects?

Doctor Answers 20

Juvederm, Are There Any Possible Side Effects?

Hi Cons,

As with any medical procedure there are risks and complications involved in the injection of Juvederm between the brows.

I have seen and heard of one patient who has an immediate allergic reaction to hyaluronic acid products (both Juvederm and Restylane). There have been reported cases of skin necrosis (dead skin) from injecting the product directly into a blood vessel. Along the same lines, there have been reported cases of blindness from injecting into the orbit.

Best to choose your injecting physician most carefully. Good luck and be well.

Dr. P


Encino Facial Plastic Surgeon
5.0 out of 5 stars 24 reviews

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What are the side effects of Juvederm in the Glabella area.

 Besides the typical, needle based therapy, of bruising and swelling...injecting any filler like Restylane, Juvederm etc. in the Glabellar area has the risk of skin necrosis of the forehead.  When any thick material is injected in the glabella, it has the possibilty of collapsing the vein that caused skin necrosis of the forehead.  This has been well documented and IMHO this is an absolute contraindication for using any fillers in this area.  Botox or Dysport will soften unwanted lines and wrinkles, save the fillers for the face.

Francis R. Palmer, III, MD
Beverly Hills Facial Plastic Surgeon
4.5 out of 5 stars 12 reviews

Botox is primary treatment of "11 lines" but filler can be beneficial

Botox to weaken the corrugator muscles will give you the most benefit with regard to reducing your "11s." If you still have a residual wrinkle this is likely imprinted on the skin and can be improved with Restylane or Juvederm. This can be difficult to treat without causing a bumpy contour or revealing the filler product so consult with an experienced injector before pursuing filler in the area between the brows.

Stephen Weber MD, FACS

Stephen Weber, MD, FACS
Denver Facial Plastic Surgeon
5.0 out of 5 stars 71 reviews

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Common Side Effects: Bruising and Swelling

It’s not unusual for patients with deeply etched vertical glabeller frown lines to require dermal fillers in addition to Botox. When this scenario arises, Juvederm can provide excellent clinical results. Although rare, side effects occasionally occur following this type of treatment.
The most common complications seen following this procedure include bruising and swelling.These typically resolve with the passage of time. Rarely patients have unsatisfactory aesthetic results which require additional filler or in some cases reversal with hyaluronidase. In rare cases, skin loss from pressure necrosis or intravascular injection may occur.
If you’re concerned about the results from Juvederm treatments, it’s important to discuss this issue with your plastic surgeon. Your surgeon should be able to address your concerns.

Juvederm Side Effects

When injected correctly, filler between the brow can have fabulous results. However, if injected incorrectly, it can have potentially serious adverse effects.The most important thing to understand when it comes to having your face injected is to go to an experienced physician injector that not only understands how to treat the face, but also can treat the possible side effects. While the most common side effects are mild -- redness, swelling and/or bruising at the injection site. In addition, a very small percentage of patients may develop a hypersensitivity reaction resulting in prolonged red, tender or swollen areas. The most serious possible effect is skin necrosis (sloughing) and even very rarely, blindness.For deep wrinkles between the brow, one may also want to consider a combination treatment of a filler and a neuromodulator such as Botox for a synergistic effect to both fill and relax the area for a natural, youthful appearance.

Mary Hurley, MD
Dallas Dermatologist
4.0 out of 5 stars 5 reviews

Juvederm or Restylane for deep frown lines between brows: Use caution.

There is a lot of confusion about what is "Botox" and what are "fillers". A lot of people think Botox is a generic term for all injectables, but the neuromodulators Botox and Dysport are muscle weakeners FDA approved for glabellar (frown lines between brows) treatment, and the fillers are not FDA approved for this area. Doctors are allowed to use fillers in the glabellar area, but there is additional risk to injecting hyaluronic acid gels there because of the danger of accidentally injecting into a vein there, which can lead to a risk of blindness. If you choose to have a physician do a small amount of filler to enhance your Botox and work synergistically there, make sure it is someone extremely experienced, well trained, and with good judgment.

Jessica J. Krant, MD, MPH
New York Dermatologic Surgeon
4.5 out of 5 stars 41 reviews

The side effects of Juvederm?

The most common side effects of Juvederm are bruising and mild swelling.  Most bruising is minimal and can be camouflaged with make-up.  Swelling from the injection site is usually gone within the first 24 hours after the procedure.  Minimal lumps and bumps are always a risk and should be discussed with you at the time of injection; however if the product is injected correctly by a trained professional this should keep this risk at minimum.

David L. Robbins, MD, FACS
West Des Moines Plastic Surgeon
4.5 out of 5 stars 16 reviews

Treating Wrinkles between the Brows

The best way to treat the wrinkles between the brows is with Botox.  Juvederm is too thick in this area and will not "freeze" the wrinkles and can potentially bruise and be lumpy.  For the best results please consult a board certified dermatologist with experience with Juvederm and Botox and other facial injections.

Juvederm side effects

The deep wrinkles located between the eyebrows are best treated with Botox, not a filler. Botox works by  paralyzing The frowning muscle to prevent contraction and scowling.  In our practice, we do not place fillers between the eyebrows due to reports in the medical  literature of necrosis in that area. When patients have significant muscle contraction of the corrugator muscle, vertical lines between the eyebrows and low eyebrows, then consideration for a brow lift. For many examples, please see the link below to our brow lift photo gallery

William Portuese, MD
Seattle Facial Plastic Surgeon
5.0 out of 5 stars 62 reviews

Minimal side effects are one of the great benefits of JUVÉDERM®

Although no treatment can 100% promise that there won’t be any side effects whatsoever, JUVÉDERM® and the other HA fillers are based on substances that are found naturally in the body, so the risk of a negative reaction is extremely low. That being said, some patients do experience mild discomfort at the injection site, and see redness or even mild bruising for a day or two. In my experience, this is mostly due to the know-how (or lack thereof) of the practitioner performing the injections. You’ll have better results and a more comfortable experience from a skilled injector.

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.