Juvederm Side Effects

I'm thinking of having Juvederm for deep wrinkles between brows. Are there any side effects?

Doctor Answers 18

Juvederm, Are There Any Possible Side Effects?

Hi Cons,

As with any medical procedure there are risks and complications involved in the injection of Juvederm between the brows.

I have seen and heard of one patient who has an immediate allergic reaction to hyaluronic acid products (both Juvederm and Restylane). There have been reported cases of skin necrosis (dead skin) from injecting the product directly into a blood vessel. Along the same lines, there have been reported cases of blindness from injecting into the orbit.

Best to choose your injecting physician most carefully. Good luck and be well.

Dr. P

Los Angeles Facial Plastic Surgeon
5.0 out of 5 stars 23 reviews

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What are the side effects of Juvederm in the Glabella area.

 Besides the typical, needle based therapy, of bruising and swelling...injecting any filler like Restylane, Juvederm etc. in the Glabellar area has the risk of skin necrosis of the forehead.  When any thick material is injected in the glabella, it has the possibilty of collapsing the vein that caused skin necrosis of the forehead.  This has been well documented and IMHO this is an absolute contraindication for using any fillers in this area.  Botox or Dysport will soften unwanted lines and wrinkles, save the fillers for the face.

Francis R. Palmer, III, MD
Beverly Hills Facial Plastic Surgeon
4.5 out of 5 stars 12 reviews

Botox is primary treatment of "11 lines" but filler can be beneficial

Botox to weaken the corrugator muscles will give you the most benefit with regard to reducing your "11s." If you still have a residual wrinkle this is likely imprinted on the skin and can be improved with Restylane or Juvederm. This can be difficult to treat without causing a bumpy contour or revealing the filler product so consult with an experienced injector before pursuing filler in the area between the brows.

Stephen Weber MD, FACS

Stephen Weber, MD, FACS
Denver Facial Plastic Surgeon
5.0 out of 5 stars 61 reviews

Juvederm or Restylane for deep frown lines between brows: Use caution.

There is a lot of confusion about what is "Botox" and what are "fillers". A lot of people think Botox is a generic term for all injectables, but the neuromodulators Botox and Dysport are muscle weakeners FDA approved for glabellar (frown lines between brows) treatment, and the fillers are not FDA approved for this area. Doctors are allowed to use fillers in the glabellar area, but there is additional risk to injecting hyaluronic acid gels there because of the danger of accidentally injecting into a vein there, which can lead to a risk of blindness. If you choose to have a physician do a small amount of filler to enhance your Botox and work synergistically there, make sure it is someone extremely experienced, well trained, and with good judgment.

Jessica J. Krant, MD, MPH
New York Dermatologic Surgeon
4.5 out of 5 stars 41 reviews

The side effects of Juvederm?

The most common side effects of Juvederm are bruising and mild swelling.  Most bruising is minimal and can be camouflaged with make-up.  Swelling from the injection site is usually gone within the first 24 hours after the procedure.  Minimal lumps and bumps are always a risk and should be discussed with you at the time of injection; however if the product is injected correctly by a trained professional this should keep this risk at minimum.

David L. Robbins, MD, FACS
West Des Moines Plastic Surgeon
4.5 out of 5 stars 16 reviews

Treating Wrinkles between the Brows

The best way to treat the wrinkles between the brows is with Botox.  Juvederm is too thick in this area and will not "freeze" the wrinkles and can potentially bruise and be lumpy.  For the best results please consult a board certified dermatologist with experience with Juvederm and Botox and other facial injections.

Juvederm side effects

The deep wrinkles located between the eyebrows are best treated with Botox, not a filler. Botox works by  paralyzing The frowning muscle to prevent contraction and scowling.  In our practice, we do not place fillers between the eyebrows due to reports in the medical  literature of necrosis in that area. When patients have significant muscle contraction of the corrugator muscle, vertical lines between the eyebrows and low eyebrows, then consideration for a brow lift. For many examples, please see the link below to our brow lift photo gallery

William Portuese, MD
Seattle Facial Plastic Surgeon
5.0 out of 5 stars 60 reviews

Minimal side effects are one of the great benefits of JUVÉDERM®

Although no treatment can 100% promise that there won’t be any side effects whatsoever, JUVÉDERM® and the other HA fillers are based on substances that are found naturally in the body, so the risk of a negative reaction is extremely low. That being said, some patients do experience mild discomfort at the injection site, and see redness or even mild bruising for a day or two. In my experience, this is mostly due to the know-how (or lack thereof) of the practitioner performing the injections. You’ll have better results and a more comfortable experience from a skilled injector.

Juvederm for frown lines

Botox is the most commonly performed cosmetic treatment in the U.S. largely because of its great success at reducting frown lines between the brows.  For very deep lines there, however, it takes months if not years to significantly reduce the depth of a furrow.  For patients with deeper lines I follow Botox treatment 2 weeks later with a filler such as Juvederm or Restylane.  I find that the filler lasts a very long time in this area when the Botox is on board, usually about 1 year or more.

Madeline Krauss, MD
Boston Dermatologic Surgeon
4.0 out of 5 stars 1 review

Juvederm for frown lines won't last long!

Frown lines (the 1, 11, or 111 wrinkles between our brows) are causes by activity of the corrugator supercilii muscles, which are facial muscles of expression. Botox or Dysport are neurotransmitter blockers that paralyze these muscles. One of these should always be used as the first method of treating these lines.

This is because any filler (HA fillers like Restylane, Juvederm Ultra, Perlane, or Juvederm Ultra Plus) placed in these expression lines without first paralyzing the muscles that cause them will only be pushed out of place by the continued activity of these untreated muscles. If your lines or furrows are deep enough to still be visible after Botox or Dysport paralysis of the muscles, then you are a good candidate for adding filler to smooth the area out.

If you decide to be "cost conscious" and use "only the filler," you may become one of those patients who complain that "my filler didn't last as long as you said it would." Of course not, the unopposed muscle activity "massaged" and "wrinkled" the filler right into the adjacent tissues and out of the wrinkle itself causing the complaint "my doctor didn't put it in the right place, he/she went 'next to' the wrinkle, not beneath it!"

Botox first, then filler if needed!

Richard H. Tholen, MD, FACS
Minneapolis Plastic Surgeon
5.0 out of 5 stars 170 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.