Juvederm Side Effects

I'm thinking of having Juvederm for deep wrinkles between brows. Are there any side effects?

Doctor Answers (15)

Juvederm, Are There Any Possible Side Effects?

+4

Hi Cons,

As with any medical procedure there are risks and complications involved in the injection of Juvederm between the brows.

I have seen and heard of one patient who has an immediate allergic reaction to hyaluronic acid products (both Juvederm and Restylane). There have been reported cases of skin necrosis (dead skin) from injecting the product directly into a blood vessel. Along the same lines, there have been reported cases of blindness from injecting into the orbit.

Best to choose your injecting physician most carefully. Good luck and be well.

Dr. P


Los Angeles Facial Plastic Surgeon
5.0 out of 5 stars 23 reviews

What are the side effects of Juvederm in the Glabella area.

+2

 Besides the typical, needle based therapy, of bruising and swelling...injecting any filler like Restylane, Juvederm etc. in the Glabellar area has the risk of skin necrosis of the forehead.  When any thick material is injected in the glabella, it has the possibilty of collapsing the vein that caused skin necrosis of the forehead.  This has been well documented and IMHO this is an absolute contraindication for using any fillers in this area.  Botox or Dysport will soften unwanted lines and wrinkles, save the fillers for the face.

Francis R. Palmer, III, MD
Beverly Hills Facial Plastic Surgeon
4.5 out of 5 stars 12 reviews

Botox is primary treatment of "11 lines" but filler can be beneficial

+2

Botox to weaken the corrugator muscles will give you the most benefit with regard to reducing your "11s." If you still have a residual wrinkle this is likely imprinted on the skin and can be improved with Restylane or Juvederm. This can be difficult to treat without causing a bumpy contour or revealing the filler product so consult with an experienced injector before pursuing filler in the area between the brows.

Stephen Weber MD, FACS

Stephen Weber, MD, FACS
Denver Facial Plastic Surgeon
5.0 out of 5 stars 37 reviews

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Juvederm side effects

+1
The deep wrinkles located between the eyebrows are best treated with Botox, not a filler. Botox works by  paralyzing The frowning muscle to prevent contraction and scowling.  In our practice, we do not place fillers between the eyebrows due to reports in the medical  literature of necrosis in that area. When patients have significant muscle contraction of the corrugator muscle, vertical lines between the eyebrows and low eyebrows, then consideration for a brow lift. For many examples, please see the link below to our brow lift photo gallery

William Portuese, MD
Seattle Facial Plastic Surgeon
5.0 out of 5 stars 58 reviews

Minimal side effects are one of the great benefits of JUVÉDERM®

+1

Although no treatment can 100% promise that there won’t be any side effects whatsoever, JUVÉDERM® and the other HA fillers are based on substances that are found naturally in the body, so the risk of a negative reaction is extremely low. That being said, some patients do experience mild discomfort at the injection site, and see redness or even mild bruising for a day or two. In my experience, this is mostly due to the know-how (or lack thereof) of the practitioner performing the injections. You’ll have better results and a more comfortable experience from a skilled injector.

Joseph J. Castellano, MD
Tampa General Surgeon
4.5 out of 5 stars 7 reviews

Juvederm for frown lines

+1

Botox is the most commonly performed cosmetic treatment in the U.S. largely because of its great success at reducting frown lines between the brows.  For very deep lines there, however, it takes months if not years to significantly reduce the depth of a furrow.  For patients with deeper lines I follow Botox treatment 2 weeks later with a filler such as Juvederm or Restylane.  I find that the filler lasts a very long time in this area when the Botox is on board, usually about 1 year or more.

Madeline Krauss, MD
Boston Dermatologic Surgeon
4.0 out of 5 stars 1 review

Juvederm for frown lines won't last long!

+1

Frown lines (the 1, 11, or 111 wrinkles between our brows) are causes by activity of the corrugator supercilii muscles, which are facial muscles of expression. Botox or Dysport are neurotransmitter blockers that paralyze these muscles. One of these should always be used as the first method of treating these lines.

This is because any filler (HA fillers like Restylane, Juvederm Ultra, Perlane, or Juvederm Ultra Plus) placed in these expression lines without first paralyzing the muscles that cause them will only be pushed out of place by the continued activity of these untreated muscles. If your lines or furrows are deep enough to still be visible after Botox or Dysport paralysis of the muscles, then you are a good candidate for adding filler to smooth the area out.

If you decide to be "cost conscious" and use "only the filler," you may become one of those patients who complain that "my filler didn't last as long as you said it would." Of course not, the unopposed muscle activity "massaged" and "wrinkled" the filler right into the adjacent tissues and out of the wrinkle itself causing the complaint "my doctor didn't put it in the right place, he/she went 'next to' the wrinkle, not beneath it!"

Botox first, then filler if needed!

Richard H. Tholen, MD, FACS
Minneapolis Plastic Surgeon
5.0 out of 5 stars 126 reviews

11 Lines - Juvederm vs. Botox

+1

The wrinkles between the eyebrows also known as the 11 lines are generally best treated initially with BOTOX, Occasionally the addition of Juvederm to fill in deep wrinkles may also be of benefit. The risk of Juvederm include bruising and or possibly lumpiness. Rarely, patients can get a localized reaction. To learn more, visit our site below.

Ankit Desai, MD
Jacksonville Plastic Surgeon
5.0 out of 5 stars 13 reviews

Juvederm and Brows

+1

Botox is the best agent used to soften the number 11's or lines between the brows.  Repeated botox injections will eliminate this line.  In deep lines, it may take as many as three sessions for this line to fade.  

Fillers can be injected here, with some risk of necrosis of skin, in this area.  Their use should be limited in a supporting role and in select patients.

Anil R. Shah, MD
Chicago Facial Plastic Surgeon
5.0 out of 5 stars 70 reviews

Botox is the better choice

+1

Juvederm can help wrinkles between the eyebrows, but, Botox is the treatment of choice. Swelling and bruising can ocrur. Lumps can develop from too much placement but this can be corrected.

Ronald Shelton, MD
Manhattan Dermatologist
5.0 out of 5 stars 31 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.