Thank you for your question. One has to make sure of the anatomical regions treated. The frown lines between the eyebrows is the glabellar region. Anything above and on the sides is considered forehead.First and foremost, you should go back to your injector for an assessment. In my 2 Visage Clinics, a normal dose for the glabella alone, for a woman, is 25-30 units, whereas for males, it is more 40-60 units. Treatment takes effect within 3-5 days for most people.45 units for both glabellar AND forehead together, for a female, would be a normal dose.There are other neuro-modulator on the market and some require a higher number of units for an equivalent effect; we have Botox, Dysport and Xeomin.The injector is the one reconstituting the neuromodulator (it comes as a powder). Make sure you see a qualified injector. And remember, there is an art in all the injections available in Canada; neuromodulators, juvederm, restylane, Selphyl, Voluma and Volbella, Radiesse, Sculptra, etc.I hope this helped!Dr. Marc DuPere, board-certified plastic surgeon, VISAGE Clinics, Toronto and Richmond Hill, voted TOP plastic surgery Clinic in Toronto for 2013 by Consumers Choice. 416.929.9800