Which Eye Drops Are Best for Droopy Eyelid Due to Botox?

Doctor Answers 27

Determine the cause first

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Most 'droopy eyes' are actually droopy eyebrows due to injection of the horizontal forehead lines (as stated by Dr. Cohen). If this is the cause the droop should improve by gently lifting up the brows. You can try to improve this type of droop by adding more Botox into the brow depressors (the frown lines) and by avoiding as much being put into the forehead lines.

If the eyelid still appears to be partially closed over the eyeball, then it is true ptosis and the iopidine (aka apraclonidine) drops can help till the Botox wears off.

Seattle Facial Plastic Surgeon
4.7 out of 5 stars 231 reviews

What Eye Drop for Droopy Eyelids after Botox?

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Hi Brenda.  Although there is no eyedrop to make the issue go away completely or immediately (only time will do that), we have found Iopidine to be helpful.  Good luck.

Harold J. Kaplan, MD
Los Angeles Facial Plastic Surgeon
4.4 out of 5 stars 7 reviews

Drooping Eyelids after Botox

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Drooping eyelids after Botox is a very rare but real side effect.  If you eyelids appear "full" due to your brows drooping then there really is not a good treatment except time for the Botox to ware off.  If your eyelids are drooping on their own but your brows are in good position, then drops such as Iopidine can be very effective.  However, you may need to take the drops several times per day for several weeks until the Botox wares off.  Good luck.

Droopy eyelid from botox

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if you have a droopy eyelid because the levator muscle was affected then Iopidine will work but if your forhead is droopy from too much or too low botox, then the eyelid falls with it and Iopidine won't help.

Ronald Shelton, MD
Manhattan Dermatologic Surgeon
4.9 out of 5 stars 39 reviews

Iopidine drops can be helpful

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Once you have determined that the droopy eyelids can not be elevated (opened up) by selectively injecting Botox to counteract the now relaxed forehead muscles, the iopidine drops can help until the effects of Botox wear off. Good luck Ms. Belcher!

Treating a droopy eyelid

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I agree that most of the time the appearance of a droopy eyelid is a result of treating the frontalis muscle (forehead) with Botox in someone who already has hooding of the eyelids. You may be able to use more Botox on the depressors medially or give a brow lift laterally.

Otherwise, phenylephrine drops work well or iopidine drops.

Brenda Dintiman, MD
Fairfax Dermatologic Surgeon

Best Eye Drops for Droopy Eyelid After Botox Injection

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Hi Ms. Belcher,

Iopidine eye drops are among the preferred drops for the treatment of weakness of the upper eyelid muscle following Botox injection.

It usually takes anywhere from days to weeks for the effect of the Botox to resolve even with the drops. So it is necessary to add some "tincture of time". I hope that you improve rapidly, and that your eyelid function is back to normal soon. Good luck.

Dr. P

Michael A. Persky, MD
Encino Facial Plastic Surgeon
4.8 out of 5 stars 39 reviews

Lopidine (apraclonidine) eye drops

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Drooping of the eylid as a result of Botox injections typically improves spontaneously by 4-6 weeks, but can last up to 3 months.

Certain medications can stimulate a certain eyelid-lifting muscle (Muller's muscle) to counteract the effect of Botox. Use of either Iopidine (apraclonidine) or phenylephrine (10%) can help with droopy eyelids until the botox wears off.

Bryan K. Chen, MD
San Diego Dermatologist

Iopidine drops may help

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There are three reasons that you may have a droopy eyelid after a Botox injection.

  1. Your eyebrow might droop which causes relatively more skin hanging over the lid
  2. You may have a naturally droopy eyelid that you have been compensating for by holding your eyebrow up. If the Botox made the eyebrow droop, you lose the compensation and you notice the naturally low eyelid
  3. The Botox might have weakened the muscle that elevates the eyelid.If the problem is cause by #2 or #3, the best droop is a prescription medication called Iopidine 5%.

If your doctor feels this is safe for you, it can be used up to 3 times a day. Visine drops (the Visine that "gets the red out") will also lift the eyelid but not as well as Iopidine.

Marc Cohen, MD
Philadelphia Oculoplastic Surgeon
4.8 out of 5 stars 26 reviews

Iopidine is best

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Having seen only 2 cases of lid droop in 12 years of injection, I can tell you this works best.

Good Luck!

Mary P. Lupo, MD
New Orleans Dermatologist
5.0 out of 5 stars 18 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.