Is hyper diluted Sculptra safe to be injected in the neck?

Hello! My name is Jessica, I am a physician assistant, and one of the providers at Aesthetic Skin - Winnetka & Chicago. This is a great question. Yes, hyperdilute Sculptra is generally considered safe for use in the neck. Sculptra, which is made of poly-L-lactic acid, works differently from traditional dermal fillers—it doesn’t provide immediate volume but instead stimulates the body to produce its own collagen over time. When hyperdiluted, Sculptra is mixed to create a thinner solution that spreads more easily across broader, delicate areas like the neck. This makes it particularly useful for improving skin texture, firmness, and the appearance of crepey skin rather than adding bulk. Because the neck has thinner skin and a more complex anatomy with underlying muscles and vessels, precise injection technique and conservative dosing are crucial to minimize risks such as nodule formation or uneven texture. Most patients tolerate the treatment well and notice gradual improvement over a few months, with results that can last up to two years. I hope this helps and best of luck!

Personally, I prefer not to inject Sculptra into the neck. Sculptra needs to be placed relatively deep to minimize the risk of forming palpable nodules. However, most neck injections are performed superficially—just beneath the skin—which increases the potential risk, even when using diluted Sculptra. Typically, patients prefer skin-tightening treatments for the neck. If volume restoration is needed, I recommend fat grafting over Sculptra injections in this area.

Hello SarahGG and thank you for your question! Hyperdilute Sculptra can be safe for the neck, but only when done by someone with the right training and experience—which is why you're getting mixed answers. Some providers use it off-label to help improve loose or crepey skin by boosting collagen, and when it's properly diluted and injected at the right depth, it usually works well and safely. But the neck is a sensitive area with thinner skin, so if it's done incorrectly, it can cause lumps or other issues. Some providers avoid it because of these risks or because it's not officially approved for the neck. If you're thinking about it, choose someone who does this treatment often, can explain how they do it, and has good results to show. Best of luck!
Genie Alexander for Anna Petropoulos, MD FRCS
Center for Classic Beauty
Boston & Danvers, MA