There is a great body of evidence based literature to show that Platelet Rich Plasma injections are safe, effective, and long lasting (Sclafani, et al.,, in particular). As an original doubter in this procedure, I have become a believer after a 11/2 year experience. As far as other fillers go, I am not aware of many that are FDA approved except for injection to the nasolabial folds; so, almost all fillers are used off label for facial filling, including Platelet Rich Plasma, Juvederm, Restylane (exception: lips), Radiesse, etc. There is also evidence based literature showing that hyaluronic acids, such as Juvederm and Restylane, increase the effectiveness of the Platelet Rich Plasma Injections, both in wound healing and facial filling. The combined physician experience with Platelet Rich Plasma extends over 6 years now, so the treatment is not new. Because the activated plasma diffuses through the tissue when massaged, I have not seen lumps, nor have I seen irregular reabsorption. I am having it done on myself, having avoided fillers up until now. I like the safety profile and the natural looking appearance.