Can hyaluronic acid fillers reach or affect the brain after absorption and time?

Recently about 1 year ago it said on the juvederm website that there has been no studies whether it has any affect or can reach the brain. One or the other. I cannot find that know. Has there been a recent clinical trial on it? As the filler gets absorbed, can it get into the bloodstream and cross the blood brain barrier. If so, what affect can it have?