I always seperate my treatments. Why? Because PRP can cause swelling that may carry the Botox away from the area its meant to stay. I perform BOTOX one to seven days before PRP. This gives the safest and most predictable results. Doing both on the same day may result in Botox diffusion, not a good idea. All the best,Dr Davin LimLaser and aesthetic dermatologistBrisbane, Australia.