Thank you for your question regarding whether your thighs can be fixed after losing 100 pounds. Congratulations on your weight loss. You will now probably live longer. It would be best if you focused on your weight loss and the significant health benefits you have achieved from it. Regarding your thighs, I would suggest a thigh lift, thigh reduction, or thigh plasty. During this procedure, thigh liposuction is combined with skin removalskin. You may even wanter 360-leg liposuction, which means liposuction on the front, inner, and outer thighs. Once thigh liposuction is performed, you may consider returning 6-8 months later for a final thigh plasty. If the skin around your knees bothers you, I suggest an incision from the groin to the knee. This incision removes a sizeable elliptical area of skin and fat between the thighs. IF the inner knee does not necessarily bother you and it is only the upper thigh, then I suggest an incision would be made from the groin down to where the thighs stop touching; in your case, this would be the middle of the inner thigh. This would be a modified or limited T-incision thigh plasty. Thigh plastics take approximately 3-4 hours to perform and are performed under general anesthesia. You will need to wear your garment for about 6-8 weeks after your thigh plasty and remain for approximately 2-3 weeks. Thank you for your question regarding whether your thighs can be fixed after losing 100 pounds. I specialize in thigh lifts. I hope that I have answered your questions regarding the thigh reduction. If you have any more questions regarding the thigh lift, thigh reduction, vertical thigh lift, medial thigh lift, spiral thigh lift, crescent thigh lift, or thigh lipo, please contact my office. Please seek an experienced, board-certified plastic surgeon with significant experience performing thigh lifts. Do your research. Make sure your chosen plastic surgeon has performed at least 100 thigh lifts. Make sure they have the before and after pictures to prove it. Carefully examine their before and after pictures and check their reviews on RealSelf. Sincerely, Dr. Katzen. (“Verified” Plastic Surgeon, President of the American Society of Bariatric Plastic Surgeons, Certified by the American Board of Plastic Surgery, Fellow of the International Society of Aesthetic Plastic Surgery, American College of Surgery, International College of Surgery, and American Board of Metabolic and Bariatric Surgery, and member of the American Society of Plastic Surgery, American Academy of Cosmetic Surgery and RealSelf Hall of Fame.)