Is lipolysis of double chin a safe procedure and does it interfere with chin or jawline filler later on?

If you are referring to lipolysis of the submental area (neck under the chin) with a product like Kybella, this is considered a safe treatment. The risk of complications such as nerve injury are possible but very rare. The treatment will not interfere with fillers but may make liposuction and insertion of threads more difficult in the future due to fibrosis caused by the treatment. If you have significant amount of fat or you want more precise contouring, you may be better off just having a liposuction by an experienced surgeon. The results will be better and it's one and done rather than multiple treatments with down time. Lipolysis often requires 3-6 treatments for best results and the swelling can be significant with each treatment.

Hello and thank you for your question! Yes, lipolysis for the double chin—whether via injectable deoxycholic acid (like Kybella or Belkyra) or devices like CoolSculpting or radiofrequency—is generally considered safe when performed by an experienced provider. It works by breaking down fat cells, which your body then clears naturally over a few weeks. Common side effects include swelling, bruising, numbness, and temporary firmness in the treated area.

It does not interfere with chin or jawline filler, but timing is important. Ideally, complete your fat reduction treatments first, as swelling and tissue changes from lipolysis can affect how filler settles. Most practitioners recommend waiting at least 4 to 6 weeks after your last lipolysis session before getting filler to allow inflammation to resolve and see your final contour. Done in the right sequence, both treatments can complement each other well for a more defined jawline.

Best of luck!

Genie Alexander, RN BSN
for Anna Petropoulos, MD FRCS
Center for Classic Beauty
Boston & Danvers, MA