Is 0.25ml of filler enough to give natural look to my nasolabial folds? (photos)

I recommend fillers to soften the nasolabial folds themselves and also lift around the mouth and cheeks to build underlying anatomical support. In our practice we combine Sculptra with other fillers "layered" on top and lasers, skin tightening treatments such as Thermage, Fractora, and Renuvion (J Plasma), thread lifting, and peels to get the most conservative, natural look. I suggest seeing a facial sculpting expert for a formal consultation. Best, Dr. Emer

I actually wouldn't recommend putting filler there, especially at your age. Instead, I would recommend using Radiesse on your cheeks to provide a lift and minimize your marionette lines - it gives a beautiful, natural lift and shape to the cheek, which will in turn lift your nasolabial area (try gently lifting your cheeks in the mirror and watch those lines disappear). Radiesse is also long-lasting and helps stimulate collagen production, so it would be an excellent choice for you! 

Hello and thanks for your question. 0.25ml per side is a very small amount and really not much to make a difference. The other option is to think about Midface/cheek filler as this will lift and support the lower face. Always go to a qualified and experienced practitioner for any injectable treatment, best wishes