Botox etc has completely stopped working, is it possible it will ever work again?

The majority of aesthetic practices administer botulinum type A toxins. Myobloc is a botulinum toxin type B toxin and can work in patients that have stopped responding to the type A toxins. Another option is stopping neurotoxin altogether for 3 years has been successful for some patients to regain effectiveness.

It sounds like you may have had too much of the neuromodulation her at one time. Once you reaches certain threshold, with Botox it is 300 units, your body will make antibodies and will neutralize the botulinum protein so it will not work.

The active molecule of every branch of neural modulator is a small protein called the light chain. The size of this protein is small and goes below the detection level of the immune system. Once the amount of protein injected reaches a certain threshold to triggers your system to believe there is a danger and your body naturally synthesizes antibodies rendering the light chain protein useless. For scientist studying neurotoxins, they are given an inactivated protein vaccine to purposely give them antibodies to prevent poisoning.

A botulinum toxin antibody test will prove whether you have antibodies or not.