Does beta-carotene impact the longevity or lead to the breakdown of dermal fillers?

Question

I've noticed a correlation in myself. I'm wondering if this has been medically looked into

Anna Chacon, MD, FAAD · Answer

Thank you for this thoughtful question — it’s great that you’re paying close attention to how your body responds to supplements and treatments.

Let’s break this down in a clear and realistic way:

What beta-carotene is

Beta-carotene is a plant pigment and a precursor to vitamin A. It’s found in carrots, sweet potatoes, leafy greens, and many supplements. Once ingested, the body can convert it into retinol (active vitamin A), which plays roles in vision, immune function, and skin health.

Dermal fillers and how they work

Dermal fillers (like hyaluronic acid fillers) are substances placed under the skin to add volume, smooth lines, or lift areas. They are eventually broken down by your body’s natural metabolic processes — enzymes, immune activity, and cellular turnover all contribute to this.

Is there a known link between beta-carotene and fillers breaking down faster?

To date, there isn’t solid clinical evidence showing that beta-carotene directly accelerates the breakdown of dermal fillers. Most of the research around filler longevity focuses on factors like:

The type of filler used

Injection technique

Metabolism

Areas of high movement

Individual enzymatic activity
There isn’t well-established scientific evidence that specific foods or supplements — including beta-carotene — significantly alter the physical breakdown of fillers.

Why you might feel there’s a connection

Your observation is important — individual responses vary. A few possibilities to consider:

Increased metabolism or supplement effects on skin turnover: Some people find that retinoids and strong vitamin A derivatives can influence skin and collagen remodeling, but beta-carotene is much gentler and regulated by the body, making excess effects uncommon.

Changes in diet, hormones, or activity: These can affect how your tissue responds over time.

Perception of change: Fillers naturally soften and integrate with surrounding tissue over weeks to months. That transition can feel like “breakdown,” especially when comparing photos or textures.

What the evidence says

There’s no credible medical study showing that beta-carotene (from diet or supplements) shortens filler lifespan. Most filler studies examine the product and technique — not dietary micronutrients. Beta-carotene isn’t known to have enzymatic activity that would dissolve filler material.

Bottom line

No strong evidence that beta-carotene directly impacts filler longevity.

Natural filler breakdown is expected over time and varies from person to person.

Your experience is valid, but the correlation may not be causal.

If you ever notice rapid changes that concern you, it’s helpful to track timing, diet, supplements, and other factors, not just one in isolation.

Thanks again for asking, curiosity and self-awareness are important parts of skincare and cosmetic treatments!

Does beta-carotene impact the longevity or lead to the breakdown of dermal fillers?

Answers (1)

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