Adding serums during microneedling can enhance results, particularly when using serums containing growth factors or hyaluronic acid, as these have been shown to improve skin hydration, texture, and healing compared to microneedling alone. Growth factor serums used with microneedling have demonstrated improvements in skin hydration, texture, smoothness, and evenness of tone, with both patient and dermatologist assessments supporting these benefits. Hyaluronic acid serums can lead to faster recovery, reduced bruising, and a higher proportion of patients achieving "good" or "very good" results, with minimal side effects. Laser vs. microneedling: Both are effective for skin rejuvenation, but the choice depends on your specific skin concerns, downtime tolerance, and risk profile. Lasers may offer more dramatic results for certain issues (like deep wrinkles or pigmentation), but also carry higher risks of side effects and longer recovery, especially in older skin. Microneedling is generally safer, with fewer side effects and shorter downtime, and can be enhanced with serums. Aspirin (81 mg daily): Low-dose aspirin can increase the risk of bruising and minor bleeding with microneedling, but this risk is generally low. Most studies report minimal side effects, though you may notice slightly more bruising than someone not on aspirin. There is no absolute contraindication, but be aware of this increased risk. In summary: Add-on serums during microneedling can provide better results than microneedling alone, especially for hydration and texture. Both microneedling and laser are effective, but microneedling is generally safer and has less downtime, which may be preferable at age 73. Your daily low-dose aspirin may slightly increase bruising risk, but this is not a major concern for most patients.