Kybella is a form of a liver salt that is syntheic and works to damage fat cells when it is injected into them. In the clinical trials, 2 treatments a month apart had close to 50% improvement in fat reduction with some neck skin tightening/lifting (but this was a secondary outcome). More treatments, gave more improvement. In general it will take 4-6 treatments to get close to 75%+ improvement in most patients. There is pain and swelling during and after injection that can last a few hours to a few weeks/months. I suggest a formal consultation with a physician who is trained and speaks on neck rejuvenation, contouring and lifting. I am one of the few Kybella injection trainers and the majority of my practice is facial and body rejuvenation by fat removal surgical and non surgical options. Some people may benefit better from surgical lipocontouring and get more jawline and lower face improvement, as well as neck lifting, quickly -- within 3 days after the procedure. Kybella is not FDA approved to use in other areas other than the fat pad under the chin/submental area, and use in other areas could be unsafe. Again, please see an expert if you are considering treatment with this new medication. It does offer a great advance in our ability to reduce fat and contour the face. Only a select number of physicians will be injecting this medication at the beginning. If you gain weight, nobody knows if the area will return, but it can even after liposuction in my opinion. Best, Dr. Emer.