What is the difference between Restylane Defyne and Restylane Refyne?

We have about 15 different fillers. Our practice does a lot of fillers so we stock every single one of them. Most of them are HA's and those differ essentially by the viscosity. So some are like water, some like honey, some like hard rubber. We choose different ones for different layers and areas of the face.Find a Doc you trust and be clear with your goals.Best of luck,DrC

Restylanes Refyne and Defyne are both great products but vary in their particle size and stiffness. Refyne is smaller and more flexible. Better suited for around the lips and fine lines. Defyne is slightly larger and stiffer. So I tend do you this for the marionette lines and NL folds. See an expert who is comfortable with a wide range or products. 

Hi, I’m Lauren, the aesthetic injector at Colorado Plastic Surgery Center. Restylane Refyne is designed for moderate smile lines like the nasolabial folds or the marionette lines. Restylane Defyne is designed for deeper lines and folds; it offers more structure and support.

Restylane Defyne and Restylane Refyne are Hyaluronic Acid dermal fillers. They are flexible fillers and help to maintain natural movements. Defyne is typically used to treat deeper areas by smoothing creases and smile lines, while Refyne is used to treat more surfaced lines because it is finer. Additionally, Refyne treats moderate wrinkles and folds and Defyne fills deeper lines while also plumping. Both should last up to one year post injection.

Thee difference between Refyne and Defyne is the Texture. Defyne is thicker while the Refyne is re Smoother. Both have great natural movement and expressions while another difference is Defyne can be used for areas that require a more deeper treatment. 
Best,
Dr. Anil Shah, MD FACS 

Thank you for the great question.
Both belong to the Restylane family of hylaronic acid injectable dermal fillers.  Restylane Refyne was approved for mid-to-deep injection into the facial tissue for the correction of moderate to severe facial wrinkles and folds.  Restylane Defyne is approved for the correction of moderate to severe deep facial facial wrinkles and folds. 
Both of these gel fillers is made with a flexible hyaluronic acid filler which uses XpresHAn Technology – creating gels that offer a wide range of flexibility and support.  This gel moves and molds with your natural movement and then returns to its natural shape – so it is perfect for the areas of the face where there is a lot of movement such as the nasolabial folds and laugh lines around the mouth. They provide excellent results for animated areas of the face where we want to maintain natural movements and expressions.
Both of these fillers last up to 12 months compared to regular Restylane which lasts approximately 6-9 months.  
As always, an in-person consultation with a board certified dermatologist with cosmetic training is the best way to assess your needs and provide medical advice. 

Both of these dermal fillers use the same technology and are very similar. Defyne is for deeper wrinkles and Refyne is for softer or shallower wrinkles. Have a formal consultation to see which dermal filler is best for you. Both can be sued in the tear trough and lips.
Best wishes, Dr. ALDO 

Thank you for your question. Our patients are very happy with the results we are able to achieve with Restylane Defyne and Refyne. Restylane Refyne is approved for mid to deep injection into the facial tissue for the correction of mild to moderate facial wrinkles, smile lines and folds by adding volume.  Restylane Defyne is for the correction of moderate to severe wrinkles, smile lines and folds, such as nasolabial folds, providing shape and contour.  Both fillers are long lasting, up to 12 months. 

Thank you for your question about Restylane Defyne and Refyne.  Because there is no filler that is "one size fits all", injectable HA fillers come in many formulations and cross-linkages.  This means we have access to fillers that are thicker and more sturdy (Voluma, Lyft) to support the midface and help revolumize those areas...as well as those that are very smooth more liquid to use in areas such as perioral lines and lips.  In between the "thick" and "thin" fillers your have several other levels of cross linkage.  Restylane Defyne and Refyne fall in this middle area.  Defyne is bit thicker than Refyne, and is good to treat areas of the face that animate frequently but need correction.  Refyne is a bit smoother/softer than Defyne and can refine more superficial lines.  Both of these products will maintain their structure, but allow for very natural movement of the face. 
To be sure, see two or more
experienced, licensed and board-certified providers in your area for a complete
evaluation to make sure you are a good candidate and that it is safe for you to
have treatment.
I hope this helps.

Since there is no single filler that "does it all", the companies making hyaluronic gels develop new formulations that expand uses and increase patient satisfaction.Dermal Fillers run the gamut from fairly liquid to firm. Since the same filler that's made for tiny lip lines won't provide the support needed to correct facial folds, you see a lot of choices in between.Refyne and Defyne use a cross-linking system that keeps them very flexible in the areas around the mouth such as laugh lines. Flexibility in those mobile areas is important because you ideally want to maintain your correction AND maintain your natural expressions. High movement areas tend to shorten the longevity of fillers in general and manufacturers are keen to create fillers that are able to move fluidly, but still last a reasonable amount of time.Refyne is a little softer than Defyne. Very often a patient will benefit from the use of a variety of filler formulations to get the best outcomes.