What is the difference between Restylane Defyne and Restylane Refyne?

Thee difference between Refyne and Defyne is the Texture. Defyne is thicker while the Refyne is re Smoother. Both have great natural movement and expressions while another difference is Defyne can be used for areas that require a more deeper treatment. 
Best,
Dr. Anil Shah, MD FACS 

Restylanes Refyne and Defyne are both great products but vary in their particle size and stiffness. Refyne is smaller and more flexible. Better suited for around the lips and fine lines. Defyne is slightly larger and stiffer. So I tend do you this for the marionette lines and NL folds. See an expert who is comfortable with a wide range or products.