What is the difference between Restylane Defyne and Restylane Refyne?

Thee difference between Refyne and Defyne is the Texture. Defyne is thicker while the Refyne is re Smoother. Both have great natural movement and expressions while another difference is Defyne can be used for areas that require a more deeper treatment. 
Best,
Dr. Anil Shah, MD FACS 

Thank you for the great question.
Both belong to the Restylane family of hylaronic acid injectable dermal fillers.  Restylane Refyne was approved for mid-to-deep injection into the facial tissue for the correction of moderate to severe facial wrinkles and folds.  Restylane Defyne is approved for the correction of moderate to severe deep facial facial wrinkles and folds. 
Both of these gel fillers is made with a flexible hyaluronic acid filler which uses XpresHAn Technology – creating gels that offer a wide range of flexibility and support.  This gel moves and molds with your natural movement and then returns to its natural shape – so it is perfect for the areas of the face where there is a lot of movement such as the nasolabial folds and laugh lines around the mouth. They provide excellent results for animated areas of the face where we want to maintain natural movements and expressions.
Both of these fillers last up to 12 months compared to regular Restylane which lasts approximately 6-9 months.  
As always, an in-person consultation with a board certified dermatologist with cosmetic training is the best way to assess your needs and provide medical advice.