Hello. CO2 stands for carbon dioxide which is the "medium" by which the laser beam is created. All lasers have something that helps them create the laser beam - common sources are solid (i.e. rubies), liquids (i.e. dye), or gas (i.e. CO2). In the old days CO2 lasers could only lay down a solid beam -which would "ablate" or remove an entire skin surface. We call this "traditional CO2 resurfacing." About a decade ago this was substantially improved by "fractionating" the beam - meaning that only a fraction of the skin was treated and healing occurred from normal, unaffected skin. When this technology was created, the healing time and safety window were substantially improved. Most CO2 treatments today are "fractional." That being said, there are a wide range of fractional CO2 lasers out there and they all have their differences. In our clinic, we use the Lumenis Ultrapulse CO2 with DeepFx and ActiveFx.Hope that helped.