This is a really insightful question, and I can understand why you’d connect the two—especially with the mention of hyaluronidase, which is something we actually use in aesthetics to dissolve fillers. How Fillers Break Down Most facial fillers are made of Hyaluronic Acid, which naturally breaks down over time in the body. In aesthetic medicine, we use Hyaluronidase—an enzyme that specifically targets and dissolves hyaluronic acid fillers when needed. Does Your Body Produce Hyaluronidase During an Infection? Yes, the body can produce small amounts of enzymes, including hyaluronidase, during certain inflammatory or infectious processes. However: The amount produced is very minimal and localized It is not directed toward dissolving filler It does not circulate in a way that would significantly affect facial fillers So, Will a UTI or Kidney Infection Dissolve Fillers? In short: No, not in any meaningful or noticeable way. Even with infections like a Urinary Tract Infection or a kidney infection: Fillers in the face remain stable You would not expect sudden loss of volume due to the infection What You Might Notice Instead If anything, during an illness: Temporary fluid shifts or inflammation can slightly change how your face looks Mild swelling or dehydration may make fillers appear a bit different temporarily But this is not the same as dissolving the filler. Bottom Line Infections like UTIs do not dissolve facial fillers Only injected hyaluronidase in a clinical setting can reliably break them down Any changes you notice during illness are usually temporary and not structural