Thank you for your question! It is not uncommon for patients to have a brief period of time that they experience some redness and itching when initiating the use of Latisse. Typically, my skin care nurse Annie Bruno and I advise our patients to "break through" the short period of discomfort and continue to use the product if they can tolerate it. If redness and itching persists for more than a few weeks, you may consider trying a different treatment (ie: lash extensions, lash curling, lash tinting). Keep in mind that Latisse is the only FDA-approved lash stimulator. Always exercise caution when treatments are being performed in or around the eye area. Be well,Dr. Todd Hobgood, MD