Can serrapeptase interfere with collagen producing injections like PRP, PRF, and Sculptra?

Serrapeptase is a proteolytic enzyme with strong anti-inflammatory and fibrinolytic properties — meaning it helps reduce swelling and break down non-living protein tissue (like fibrin).
While this can be beneficial for reducing post-surgical inflammation, it also means that, if taken too soon after collagen-stimulating procedures such as PRP, PRF, or Sculptra, it might interfere with the early inflammatory phase that’s essential for collagen synthesis and tissue remodeling.

However, once you’ve passed the first 10–14 days — when fibroblasts begin producing new collagen — serrapeptase no longer disrupts this process.
In fact, after the acute healing phase, it may help by improving microcirculation and reducing excessive fibrosis or nodules, especially in patients with a tendency for over-repair.

So your assumption is correct:

Avoid serrapeptase for 1–2 weeks before and after PRP/PRF/Sculptra.

Beyond that window, it does not interfere with ongoing collagen production and can be safely used for other health concerns.

Dr. Arslan Musbeh
Hair Transplant Surgeon – Founder of Hairmedico
17+ years of experience in FUE, Sapphire FUE, and DHI

This answer has been approved by Dr. Arslan Musbeh. It is not a medical advice.