Latisse is safe to use for contact users. Be sure to remove contacts before applying Latisse in the nights.
Latisse should be applied to the upper eyelids only - and usually it's preferred to do this at night. That way, when you close your eyes to sleep, the lids will touch and transfer the solution to the lower lids as well. Take your contacts out before applying the Latisse, and everything should be just fine. There are many, many, many people who successfully use Latisse and wear contacts. "This answer has been solicited without seeing this patient and cannot be held as true medical advice, but only opinion. Seek in-person treatment with a trained medical professional for appropriate care."