Is it safe to have Botox if you have SLE?

There is no contraindication to Botox treatment in patients with SLE. With that said, you should discuss your medical history with your physician injector to ensure that you are a good candidate. I hope this information is helpful for you.Stephen Weber MD, FACSDenver Facial Plastic Surgeon 

I concur with Dr Green, discuss your desire to have Botox treatment with your rheumatologist. I am not aware of any contraindications for patients with autoimmune conditions.

I would consult with your rheumatologist who is treating and following your for SLE.  Provided you have no neurologic symptoms they will probably give you the medical clearance to have Botox.  Again, I would consult with your treating physician before having injections.