You can definitely apply creams or lotions after Botox or facial fillers. I tell my patients not to massage the treated area for 72 hours so that you do not affect the results. Sunscreen should be applied daily.
I ask my patients to leave their faces alone for 4 hours after injecting Botox or fillers. After that time, they may continue with their normal cleansing and moisturizing after Botox treatment, but should avoid anti-aging products, massaging or exfoliating for 1 to 2 days after fillers to prevent any irritation.